Research

We use human genetics and immunology to discover mechanisms of immune defense and dysregulation, and to translate these insights into better diagnosis and therapy.

Exploration of Novel IEIs

Discovering and characterizing new inborn errors of immunity underlying severe infection, immune dysregulation, and malignancy.

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MAVEs for Key IEI & Cancer Genes

Multiplexed assays of variant effect to map genotype–function relationships and enable accurate, timely genetic diagnosis.

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Therapeutics for IEIs and Beyond

Building precision therapeutic strategies informed by human genetics, including targeted immunomodulation and translational pathways to intervention.

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Disease-causing Autoantibody (aAb) Discovery

Discovering novel disease-causing autoantibodies by leveraging existing platforms and developing new screening technologies.

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